Abstract
A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12.
MeSH terms
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Animals
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Boronic Acids / chemistry
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Catalysis
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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In Vitro Techniques
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Indicators and Reagents
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Ligands
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Palladium
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Rats
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Receptors, Corticotropin-Releasing Hormone / drug effects*
Substances
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2-benzyloxy-4-chloro-3-nitropyridine
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Boronic Acids
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Imidazoles
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Indicators and Reagents
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Ligands
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Pyridines
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Receptors, Corticotropin-Releasing Hormone
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Palladium